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2 article(s) from Helfrich, Eric J N

Navigating and expanding the roadmap of natural product genome mining tools

Friederike Biermann,
Sebastian L. Wenski and
Eric J. N. Helfrich

Beilstein J. Org. Chem. 2022, 18, 1656–1671, doi:10.3762/bjoc.18.178

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Graphical Abstract

Figure 1: Examples of prominent natural products: N-butyrylhomoserine lactone (1), pyoverdin (2), malleicypro...

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Figure 2: Biosynthetic principles of (A) assembly line-like pathways and (B) discrete multi-enzymatic assembl...

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Figure 3: Universal (A, B, F) NP class and NP family-specific (C, D, F) signature sequences in NP BGCs and se...

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Figure 4: Concepts of algorithms in order of complexity and examples of genome mining tools that employ the r...

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Figure 5: Examples of peptide NPs, the corresponding BGCs of which were determined through retrobiosynthetic ...

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Figure 6: gcBGC prioritization process. The bar represents all identified gene clusters in one organism and i...

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Figure 7: Genome alignments of related organisms revealing the presence of syntenic (purple) as well as non-s...

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Perspective

Published 06 Dec 2022

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Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering

Eric J. N. Helfrich,
Geng-Min Lin,
Christopher A. Voigt and
Jon Clardy

Beilstein J. Org. Chem. 2019, 15, 2889–2906, doi:10.3762/bjoc.15.283

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Figure 1: Examples of bioactive terpenoids.

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Figure 2: Repetitive electrophilic and nucleophilic functionalities in terpene and type II PKS-derived polyke...

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Figure 3: Abundance and distribution of bacterial terpene biosynthetic gene clusters as determined by genome ...

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Figure 4: Terpenoid biosynthesis. Terpenoid biosynthesis is divided into two phases, 1) terpene scaffold gene...

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Figure 5: Mechanisms for type I, type II, and type II/type I tandem terpene cyclases. a) Tail-to-head class I...

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Figure 6: Functional TC characterization. a) Different terpenes were produced when hedycaryol (18) synthase a...

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Figure 7: Selected examples of terpene modification by bacterial CYPs. a) Hydroxylation [89]. b) Carboxylation, h...

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Figure 8: Off-target effects observed during heterologous expression of terpenoid BGCs. Unexpected oxidation ...

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Figure 9: TC promiscuity and engineering. a) Spata-13,17-diene (39) synthase (SpS) can take C₁₅ and C₂₅ oligo...

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Figure 10: Substrate promiscuity and engineering of CYPs. a) Selected examples from using a CYP library to oxi...

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Figure 11: Engineering of terpenoid pathways. a) Metabolic network of terpenoid biosynthesis. Toxic intermedia...

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Review

Published 29 Nov 2019

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